Methyl Ethyl Ketone → Ethyl 4-(2-Piperidinoethoxy)benzoate

Temperatur

80 °C

A mixture of ethyl 4-hydroxybenzoate (8.31 g), 1-(2-chloroethyl)piperidine monohydrochloride (10.13 g), potassium carbonate (16.59 g), and methyl ethyl ketone (60 mL) was heated to 80° C. After one hour, the mixture was cooled to about 55° C. and treated with additional 1-(2-chloroethyl)piperidine mono-hydrochloride (0.92 g). The resulting mixture was heated to 80° C. The reaction was monitored by thin layer chromatography (TLC), using silica-gel plates and ethyl acetate/acetonitrile/triethylamine (10:6:1, v/v). Additional portions of 1-(2-chloroethyl)piperidine hydrochloride are added until the starting 4-hydroxybenzoate ester is consumed. Upon complete reaction, the reaction mixture was treated with water (60 mL) and allowed to cool to room temperature. The aqueous layer was discarded and the organic layer concentrated in vacuo at 40° C. and 40 mm Hg. The resulting oil was used in the next step without further purification.

1. temperaturethe mixture was cooled to about 55° C.
2. temperatureThe resulting mixture was heated to 80° C
3. customis consumed
4. customUpon complete reaction
5. temperatureto cool to room temperature
6. concentrationthe organic layer concentrated in vacuo at 40° C.
7. customThe resulting oil was used in the next step without further purification

ORD-Eintrag

ord-ae3cb0dae3e944c48580e55737574b4a

Quelldatensatz

uspto-grants-2004_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06713494B1