Acetic Acid → 5-chloro-1H-pyrrolo(2,3-b)pyridine-3-carbaldehyde
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]2[CH:10]=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.C1N2CN3CN(C2)CN1C3.[C:21](O)(=[O:23])C>O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:10]([CH:21]=[O:23])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
In a round bottom flask, 5-chloro-1H-pyrrolo[2,3-b]pyridine (1, 10.0 g, 65.5 mmol) was combined with hexamethylenetetramine (11.9 g, 85.2 mmol), acetic acid (28.3 mL, 0.498 mol) and 56.7 mL of water. The reaction was heated at reflux overnight, then 200 mL of water was added. After 30 minutes, solid material was collected by filtration and dried to give the desired compound (114, 7.0 g).
Aufarbeitung
- temperatureThe reaction was heated
- temperatureat reflux overnight
- filtrationsolid material was collected by filtration
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-f4d5c70bb0954c4ba840c615a87a0808
- Quelldatensatz
- uspto-grants-2015_08
- Patentnummer
- US09096593B2
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