Dimethylformamide → 2-Chloro-3-(trifluoromethyl)benzoyl chloride

HRID 513218

Reaktionsgleichung

Reaktionsgleichung von HRID 513218
[Cl:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].CN(C=O)C.C(Cl)(=O)C([Cl:23])=O>C(Cl)Cl>[Cl:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:23])=[O:5]

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 27366772-Chloro-3-(trifluoromethyl)benzoic acid

Produkt 1

HCID 38276332-Chloro-3-(trifluoromethyl)benzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a suspension of 2-chloro-3-(trifluoromethyl)benzoic acid (15 g, 67 mmol) and catalytic DMF (0.06 mL, 0.67 mmol) in DCM (150 mL) was added oxalyl chloride (6.8 mL, 80 mmol) dropwise. The reaction was let stir (vigorous bubbling) for 4 h and concentrated to an oily solid which became solid after overnight drying on high vacuum.

Aufarbeitung

  1. custom(vigorous bubbling) for 4 h
  2. concentrationconcentrated to an oily solid which
  3. customafter overnight
  4. customdrying on high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-7e8ac219a9984f6494b1041233e4e050
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09102686B2

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