Water → 3-Amino-6-(4-(2-hydroxyethoxy)-3-(trifluoromethyl)phenyl)-4-(methylamino)-picolinonitrile

Reaktionsgleichung

CC1(C)C(C)(C)OB([C:9]2[CH:18]=[CH:17][C:12]([O:13][CH2:14][CH2:15][OH:16])=[C:11]([C:19]([F:22])([F:21])[F:20])[CH:10]=2)O1.[NH2:24][C:25]1[C:26]([C:34]#[N:35])=[N:27][C:28](Cl)=[CH:29][C:30]=1[NH:31][CH3:32].P([O-])([O-])([O-])=O.[K+].[K+].[K+].O>O1CCOCC1.C(OCC)(=O)C.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[NH2:24][C:25]1[C:26]([C:34]#[N:35])=[N:27][C:28]([C:9]2[CH:18]=[CH:17][C:12]([O:13][CH2:14][CH2:15][OH:16])=[C:11]([C:19]([F:20])([F:21])[F:22])[CH:10]=2)=[CH:29][C:30]=1[NH:31][CH3:32]