Hydrochloric Acid → Acetamide, 2-(hydroxyimino)-N-phenyl-

HRID 51980

Reaktionsgleichung

Reaktionsgleichung von HRID 51980
[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=O)[C:2]1=[O:3].O=CC(Cl)(Cl)Cl.[Cl-].[OH:19][NH3+:20].Cl.NC1C=CC=CC=1>>[CH:8]1[CH:7]=[CH:6][C:11]([NH:1][C:2](/[CH:4]=[N:20]/[OH:19])=[O:3])=[CH:10][CH:9]=1

Komponenten

6

Edukt 5

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 6407ChloralHCID 7054IsatinHCID 21645Hydroxylamine HCl

Produkt 1

HCID 6861488Acetamide, 2-(hydroxyimino)-N-phenyl-

Versuchsvorschrift

The isatin derivative (9) can be synthesized, for example, as shown in the following reaction scheme. That is, an aqueous solution obtained by adding chloral and hydroxylammonium chloride to hydrochloride of an aniline derivative (10) as a starting material is reacted for 0.5 to 2 hours with heating at 70° to 110° C. to give an isonitrosoacetanilide derivative, and this product is cyclized with concentrated sulfuric acid and hydrolyzed to give an isatin derivative (9). ##STR10## wherein R1A to R1D are as defined above.

Aufarbeitung

  1. customas shown in the following reaction scheme
  2. customan aqueous solution obtained
  3. customis reacted for 0.5 to 2 hours
  4. temperaturewith heating at 70° to 110° C.

Quellen und Nachweise

ORD-Eintrag
ord-e75f94cdfd09486eb81e090e8b1e9b65
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05616441

Verknüpfte Notizen

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