Citric Acid → Apomorphine

HRID 520276

Reaktionsgleichung

Reaktionsgleichung von HRID 520276
C(O)[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.[CH3:13][N:14]1[C@@H:23]2[CH2:24][C:25]3[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([OH:32])[C:26]=3[C:21]3[C:22]2=[C:17]([CH:18]=[CH:19][CH:20]=3)[CH2:16][CH2:15]1.Cl.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O>[CH3:13][N:14]1[C@@H:23]2[CH2:24][C:25]3[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([OH:32])[C:26]=3[C:21]3[C:22]2=[C:17]([CH:18]=[CH:19][CH:20]=3)[CH2:16][CH2:15]1

Komponenten

5

Edukt 3

HCID 311Citric AcidHCID 6251MannitolHCID 94104H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride (1:1), (6aR)-2×

Produkt 1

HCID 6005Apomorphine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Gelatin and mannitol are dispersed in purified water and mixed thoroughly (i.e., using a vacuum mixer) and homogenized. Apomorphine hydrochloride is added and the mixture was again homogenized to ensure complete dissolution of the apomorphine hydrochloride. The pH of the solution is adjusted to about 3.0 (i.e., by addition of a suitable acid, such as citric acid). The solution is then poured onto a sheet and dried in a heated oven.

Aufarbeitung

  1. additionmixed thoroughly (i.e.
  2. stirringthe mixture was again homogenized
  3. additionby addition of a suitable acid
  4. additionThe solution is then poured onto a sheet
  5. customdried in a heated oven

Quellen und Nachweise

ORD-Eintrag
ord-1df9c2a8030f4e2683f6d2d94be875ff
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09326981B2

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