Acetic Anhydride → Acetic acid 3-(2-hydroxy-ethyl)-phenyl ester

HRID 521511

Reaktionsgleichung

Reaktionsgleichung von HRID 521511
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][OH:10])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])O.[Na+].[C:16](OC(=O)C)(=[O:18])[CH3:17]>O1CCOCC1.O>[OH:10][CH2:9][CH2:8][C:4]1[CH:3]=[C:2]([O:1][C:16](=[O:18])[CH3:17])[CH:7]=[CH:6][CH:5]=1

Komponenten

6

Edukt 3

HCID 7918Acetic AnhydrideHCID 834043-Hydroxyphenethyl alcoholHCID 516892Sodium Bicarbonate

Produkt 1

HCID 67076782Acetic acid 3-(2-hydroxy-ethyl)-phenyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

2-(3-Hydroxyphenyl)ethanol (400 mg, 2.90 mmol) was dissolved in a mixture of 4 ml of dioxane and 4 ml of water, and sodium hydrogencarbonate (2.43 g, 29 mmol) was added followed by acetic anhydride (2.96 g, 29 mmol) with ice cooling. The mixture was stirred overnight at room temperature and then partitioned between 2 N hydrochloric acid and EA. The aqueous phase was extracted with EA, the combined organic phases were dried over sodium sulfate and evaporated to dryness to yield the crude title compound which was used without further purification.

Aufarbeitung

  1. additionwas added
  2. custompartitioned between 2 N hydrochloric acid and EA
  3. extractionThe aqueous phase was extracted with EA
  4. dry with materialthe combined organic phases were dried over sodium sulfate
  5. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-1eee8947a8e040e8a10209160bf2a857
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09328071B2

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