Water → HCID 90323117, Verbindung

HRID 527198Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 527198
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)[NH2:5].N1C=CC=CC=1.Cl[C:30]([O:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:31].O>C(#N)C>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C:30](=[O:31])[O:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:6]=[CH:7][C:8]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[CH2:11][CH2:10]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 1049PyridineHCID 15891Phenyl chloroformateHCID 176097133-Fluoro-4-(4-(4-methoxyphenyl)piperazin-1-yl)aniline

Produkt 1

HCID 90323117HCID 90323117, VerbindungAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a solution of 4 (0.32 g, 1 mmol) and pyridine (0.12 mL, 1.5 mmol) in acetonitrile (4 mL, 0.25M), phenyl chloroformate (0.16 mL, 1.2 mmol) was added at 0° C. and the reaction mixture was stirred at room temperature for overnight. Then water was added and the mixture was stirred for 30 min. The precipitated white solid was filtered and the solid was washed with acetonitrile and then dried under vacuum to obtain compound 5 (0.35 g, 83%).

Aufarbeitung

  1. stirringthe mixture was stirred for 30 min
  2. filtrationThe precipitated white solid was filtered
  3. washthe solid was washed with acetonitrile
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-29b926f63f0c4de9b259f4ef280dc876
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09346791B2

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