Dimethylformamide → 2-Bromo-4'-fluoro-5-methoxybiphenyl-4-carbaldehyde

HRID 531048Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 531048
[Br:1]N1C(=O)NC(=O)N(Br)C1=O.CN(C=O)C.[F:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][C:27]([CH:30]=[O:31])=[C:26]([O:32][CH3:33])[CH:25]=2)=[CH:20][CH:19]=1>O>[Br:1][C:29]1[CH:28]=[C:27]([CH:30]=[O:31])[C:26]([O:32][CH3:33])=[CH:25][C:24]=1[C:21]1[CH:20]=[CH:19][C:18]([F:17])=[CH:23][CH:22]=1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 192912Dibromoisocyanuric acidHCID 225667274'-Fluoro-3-methoxy-[1,1'-biphenyl]-4-carbaldehyde

Produkt 1

HCID 904235612-Bromo-4'-fluoro-5-methoxybiphenyl-4-carbaldehydeAusbeute 180,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Dibromoisocyanuric acid (10.6 g) was added at 15° C. to 30° C. to a DMF (90 mL) solution of 4′-fluoro-3-methoxybiphenyl-4-carbaldehyde (16.0 g), and the mixture was stirred for 40 minutes. Then, water (30 mL) was added thereto, and the mixture was further stirred for 1 hour. The deposited solid was collected by filtration and washed with a mixed solution of DMF (15 mL) and water (15 mL) and water (30 mL) in this order to obtain the title compound (20.6 g).

Aufarbeitung

  1. stirringthe mixture was further stirred for 1 hour
  2. filtrationThe deposited solid was collected by filtration
  3. washwashed with a mixed solution of DMF (15 mL) and water (15 mL) and water (30 mL) in this order

Quellen und Nachweise

ORD-Eintrag
ord-8b661be5d8f44d37bb8fe0c8b0d3bf69
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09353108B2

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