Acetone → 2-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine

HRID 536786

Reaktionsgleichung

Reaktionsgleichung von HRID 536786
[N:1]1[C:8](Cl)=[N:7][C:5](Cl)=[N:4][C:2]=1[Cl:3].C([N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])C.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1.CC(C)=[O:25]>O>[Cl:3][C:2]1[N:1]=[C:8]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[N:7]=[C:5]([N:12]2[CH2:13][CH2:14][O:25][CH2:16][CH2:15]2)[N:4]=1

Komponenten

6

Edukt 4

HCID 180AcetoneHCID 7954Cyanuric chlorideHCID 8083MorpholineHCID 8471Triethylamine

Produkt 1

HCID 2249672-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a stirred solution of cyanuric chloride (18.4 g, 10 mmol) in acetone (100 ml) and crushed ice (500 g), a mixture of triethylamine (30.0 g, excess) and morpholine (17.4 g, 20 mmol) was added at −10° C. After the addition, reaction mixture was stirred at room temperature and for 1 hour and diluted with 50 ml water. Separated white solid was filtered and washed with water. The white solid was dried and filtered. The crude product was found to be pure and taken to next step without purification. Yield: 25 g, 87%; (M+H) 286.7

Aufarbeitung

  1. additionwas added at −10° C
  2. additionAfter the addition, reaction mixture
  3. customSeparated white solid
  4. filtrationwas filtered
  5. washwashed with water
  6. customThe white solid was dried
  7. filtrationfiltered
  8. customtaken to next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-a03be20ab11748a591d15bfc2c4c7ddb
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08859542B2

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