Hydrochloric Acid → [(2,3-Difluorobenzoyl)amino]acetic acid

HRID 539589

Reaktionsgleichung

Reaktionsgleichung von HRID 539589
[F:1][C:2]1[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([NH:6][CH2:7][C:8]([O:10]C)=[O:9])=[O:5].[OH-].[Li+].Cl>CO.O>[F:1][C:2]1[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([NH:6][CH2:7][C:8]([OH:10])=[O:9])=[O:5]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 59816250Methyl [(2,3-difluorobenzoyl)amino]acetate

Produkt 1

HCID 59816243[(2,3-Difluorobenzoyl)amino]acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel2×

Versuchsvorschrift

To a solution of methyl [(2,3-difluorobenzoyl)amino]acetate (0.250 g, 1.1 mmol) in methanol (7 mL) were added lithium hydroxide (0.053 g, 2.2 mmol) and water (3 mL). The reaction mixture was allowed to stir overnight. The mixture was diluted with water (20 mL) and acidified with 1N HCl (5 mL). The product was partitioned into DCM/methanol (4:1). The organic layer was dried over sodium sulfate and the solvent removed to give [(2,3-difluorobenzoyl)amino]acetic acid which was used in the next step without purification.

Aufarbeitung

  1. customThe product was partitioned into DCM/methanol (4:1)
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. customthe solvent removed

Quellen und Nachweise

ORD-Eintrag
ord-e403af05ceef40f88786cc3ccb137b08
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871745B2

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