Diethyl Oxalate → Ethyl 2-hydrazinyl-2-oxoacetate

HRID 541252

Reaktionsgleichung

Reaktionsgleichung von HRID 541252
[C:1]([O:8]CC)(=O)[C:2]([O:4][CH2:5][CH3:6])=[O:3].O.[NH2:12][NH2:13]>C(O)C>[NH:12]([C:1](=[O:8])[C:2]([O:4][CH2:5][CH3:6])=[O:3])[NH2:13]

Komponenten

4

Edukt 2

HCID 7268Diethyl OxalateHCID 24654Hydrazine hydrate (1:1)

Produkt 1

HCID 2786935Ethyl 2-hydrazinyl-2-oxoacetateAusbeute 88,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a round-bottom flask was added a solution of diethyl oxalate (10.0 g, 68.4 mmol, 1.00 equiv) in ethanol (100 mL). Hydrazine hydrate (2.75 g, 85.8 mmol, 1.00 equiv) was added and the resulting mixture was stirred for 3 h at 80° C. After cooling to ambient temperature, the solids were removed via filtration and the filtrate was concentrated in vacuo to yield 8.00 g (80%) of the title compound as a colorless oil.

Aufarbeitung

  1. temperatureAfter cooling to ambient temperature
  2. customthe solids were removed via filtration
  3. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9d12edd2be484311be42d75512ec3b4e
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871790B2

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