Bromoacetic Acid → HCID 57962294, Verbindung

HRID 541730

Reaktionsgleichung

Reaktionsgleichung von HRID 541730
Br[CH2:2][C:3]([OH:5])=O.[ClH:6].[F:7][C:8]([F:19])([F:18])[C:9]1[N:13]2[CH2:14][CH2:15][NH:16][CH2:17][C:12]2=[N:11][N:10]=1.Cl.CN(C)CCCN=C=NCC.C(N(CC)C(C)C)(C)C>ClCCl>[Cl:6][CH2:2][C:3]([N:16]1[CH2:15][CH2:14][N:13]2[C:9]([C:8]([F:18])([F:7])[F:19])=[N:10][N:11]=[C:12]2[CH2:17]1)=[O:5]

Komponenten

6

Edukt 4

HCID 6227Bromoacetic AcidHCID 81531DiisopropylethylamineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 119613713-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

Produkt 1

HCID 57962294HCID 57962294, VerbindungAusbeute 33 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Bromoacetic acid (300 mg, 2.2 mmol) and 3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (490 mg, 2.2 mmol) were stirred in dichloromethane (5 mL) with N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (412 mg, 2.2 mmol) and N,N-diisopropylethylamine (560 mL, 3.2 μmol) for 3 hours at rt. The mixture was washed with water, dried over sodium sulfate and evaporated to give the desired compound in 33% yield. LCMS for C8H8ClF3N4O (M+H)+: m/z=269.0.

Aufarbeitung

  1. washThe mixture was washed with water
  2. dry with materialdried over sodium sulfate
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-436f68b65c2443939f419eab38d75050
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871753B2

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