tert-Butanol → Dimethyl Isosorbide

292.3 g (2 mol) of 1,4; 3,6-dianhydrosorbitol and 800 ml of tert.-butanol were heated to 55° to 65° C. with stirring and then two separate dropping funnels were used to simultaneously add 572 g (7.14 mol) of aqueous 50% sodium hydroxide solution and 631 g (5 mol) of dimethyl sulfate dropwise at this temperature while keeping the reaction mixture always alkaline. The mixture was then stirred for three hours at about 60° C. and then most of the tert.-butanol was distilled off. The residue was mixed with 2,600 ml of water and the resulting solution was extracted three times with 500 ml portions of methylene chloride. The combined organic phases were dried over potassium carbonate and evaporated first at atmospheric pressure and then distilled under water jet vacuum to obtain 324 g (93% yield) of dimethyl isosorbide with a boiling point of 118° to 120° C. at 20 mbar.

1. customtwo separate
2. stirringThe mixture was then stirred for three hours at about 60° C.
3. distillationmost of the tert.-butanol was distilled off
4. additionThe residue was mixed with 2,600 ml of water
5. extractionthe resulting solution was extracted three times with 500 ml portions of methylene chloride
6. dry with materialThe combined organic phases were dried over potassium carbonate
7. customevaporated first at atmospheric pressure
8. distillationdistilled under water jet vacuum

ORD-Eintrag

ord-d07a8e89e05647b7adbae39ada0e118c

Quelldatensatz

uspto-grants-1987_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04659846