Benzene → 4-Fluorobenzene-1,2-diamine

4-Fluoro-1,2-diaminobenzene was prepared using an adaptation of the method of Tsuji et al. (Tsuji, Y. et al., J. Org. Chem. 55:580 (1990)). A suspension of Zn powder (10.5 g, 0.160 mol), CaCl2 (1.05 g) and H2O in 40 ml EtOH was heated to reflux with stirring under N2. To this was added slowly dropwise a solution of 4-fluoro-2-nitroaniline (2.00 g, 12.8 mmol) in 10 mL EtOH. The reaction mixture was refluxed 8 h. TLC analysis (silica gel, 2:1 benzene:EtOAc) indicated complete disappearance of the starting material. The Zn was removed by vacuum filtration, and the solvent rotary evaporated. The residue was dissolved in 50 mL Et2O and the solution extracted with 3×25 mL 1N HCl. The aqueous layers were combined and basified with 50% aq. NaOH (6 g) and the resulting solution extracted with 3×25 mL Et2O. The Et2O layers were combined and dried (MgSO4). The solvent was rotary evaporated to yield 1.36 g (84%) of a brown solid. mp 90° 92° C. 1H NMR (CDCl3) δ3.18 (brs, 2H, NH2); 3.58 (brs, 2H, NH2); 6.44 (m, 2H, ArH), 6.61 (m, 1H, ArH).

1. temperaturewas heated
2. temperatureto reflux
3. temperatureThe reaction mixture was refluxed 8 h
4. customThe Zn was removed by vacuum filtration
5. dissolutionThe residue was dissolved in 50 mL Et2O
6. extractionthe solution extracted with 3×25 mL 1N HCl
7. extractionthe resulting solution extracted with 3×25 mL Et2O
8. dry with materialdried (MgSO4)
9. customThe solvent was rotary evaporated

ORD-Eintrag

ord-5854a670d5914aab9c66b7ae4530f169

Quelldatensatz

uspto-grants-1997_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05622952