Propionic anhydride → HCID 15580731, Verbindung

Reaktionsgleichung

F[C:2](F)(F)[C:3]([NH:5][C:6]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14](C(=O)C(F)(F)F)=[CH:13][CH:12]=2)[N:7]=1)=[O:4].[C:25](OC(=O)CC)(=O)CC>CN(C)C1C=CN=CC=1.ClCCl>[C:11]1([N:8]2[CH2:9][CH2:10][C:6]([NH:5][C:3](=[O:4])[CH2:2][CH3:25])=[N:7]2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Komponenten

Versuchsvorschrift

A mixture of 10.0 g. of 3-amino-1-phenyl-2-pyrazoline (prepared as described in Example 8), 50 ml. of propionic anhydride and 200 mg. of 4-dimethylaminopyridine is kept at room temperature for 30 minutes. The mixture is cooled and filtered to give yellow crystals. The solid is dissolved in dichloromethane and is columnized and crystallized as for Example 10 (B) to yield 4.55 g. of the product of the Example as colorless crystals, m.p. 170.5°-171° C.