StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

tert-Butyl carbazate → HCID 66839551, Verbindung

HRID 546771
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 546771
[Cl:1][CH2:2][CH2:3][CH2:4]/[C:5](=[CH:9]\[C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH:20]=[C:19]([CH3:21])[N:18]=[CH:17]2)=[C:12]([O:22][CH3:23])[CH:11]=1)/[C:6](O)=[O:7].C1N(P(Cl)(N2C(=O)OCC2)=O)C(=O)OC1.C(N(C(C)C)CC)(C)C.C(OC(C)(C)C)(=O)[NH:49][NH2:50]>ClCCl.C(OCC)(=O)C.O>[Cl:1][CH2:2][CH2:3][CH2:4]/[C:5](=[CH:9]\[C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH:20]=[C:19]([CH3:21])[N:18]=[CH:17]2)=[C:12]([O:22][CH3:23])[CH:11]=1)/[C:6]([NH:49][NH2:50])=[O:7]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

8

Edukt 4

HCID 70091tert-Butyl carbazateHCID 81531DiisopropylethylamineHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideHCID 58528693HCID 58528693, Verbindung

Produkt 1

HCID 66839551HCID 66839551, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962
Water
Lösungsmittel
HCID 6344DichloromethaneLösungsmittel
HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

5-Chloro-2-[1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene]pentanoic acid (CAS No. 870843-27-9, 10 g) was dissolved in dichloromethane (130 mL). BOPCl (4.53 g), IPEA (12.3 g) and tert-butyl carbazate (2.82 g) were added and the reaction solution was stirred at room temperature for three hours. Water and ethyl acetate were added to the reaction solution, and the organic layer was separated. The organic layer was washed with a 1 N sodium hydroxide solution and 1 N hydrochloric acid in this order. The organic layer was dried over magnesium sulfate and concentrated under reduced pressure. A solution of 4 N hydrochloric acid in ethyl acetate (100 mL) was added to the residue, and the reaction solution was stirred at room temperature for two hours. The reaction solution was concentrated under reduced pressure to obtain 3.87 g of a crude product of the title compound. The property value of the compound is as follows.

Aufarbeitung

  1. customthe organic layer was separated
  2. washThe organic layer was washed with a 1 N sodium hydroxide solution and 1 N hydrochloric acid in this order
  3. dry with materialThe organic layer was dried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure
  5. additionA solution of 4 N hydrochloric acid in ethyl acetate (100 mL) was added to the residue
  6. stirringthe reaction solution was stirred at room temperature for two hours
  7. concentrationThe reaction solution was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-69a780d942354a269d8b09140546ff6f
Quelldatensatz
uspto-grants-2011_05
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US07935815B2

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion