Water → 2-Methyl-9-(2-piperidinoehtyl)-3-(2-thenoyl)imidazo[1,2-a]benzimidazole

HRID 54704

Reaktionsgleichung

Reaktionsgleichung von HRID 54704
[Br-].[NH2:2][C:3]1[N:4]([CH2:20][C:21](=[O:27])[C:22]2[S:26][CH:25]=[CH:24][CH:23]=2)[C:5]2[CH:19]=[CH:18][CH:17]=[CH:16][C:6]=2[N+:7]=1[CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.O.[C:29](OC(=O)C)(=O)[CH3:30]>>[CH3:29][C:30]1[N:2]=[C:3]2[N:4]([C:20]=1[C:21](=[O:27])[C:22]1[S:26][CH:25]=[CH:24][CH:23]=1)[C:5]1[CH:19]=[CH:18][CH:17]=[CH:16][C:6]=1[N:7]2[CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Komponenten

4

Edukt 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 1785085292-(2-imino-3-(2-(piperidin-1-yl)ethyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-1-(thiophen-2-yl)ethanone hydrobromide

Produkt 1

HCID 10498902-Methyl-9-(2-piperidinoehtyl)-3-(2-thenoyl)imidazo[1,2-a]benzimidazole

Versuchsvorschrift

The bromide obtained in Step A is heated at reflux in 15 ml of acetic anhydride until completely dissolved. Cool and pour into 50 ml of cold water. Neutralise with a solution of sodium carbonate and extract twice with 10 ml of chloroform each time. Combine the organic phases, pass over a column of alumina and evaporate. Recrystallise the residue from ethyl acetate.

Aufarbeitung

  1. dissolutionuntil completely dissolved
  2. temperatureCool
  3. extractionNeutralise with a solution of sodium carbonate and extract twice with 10 ml of chloroform each time
  4. customevaporate
  5. customRecrystallise the residue from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-2e6e298763f54385911e75ee60b5a7f6
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05623073

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