Isopropylamine → 2-Chloro-N-isopropyl-4-pyrimidinamine

HRID 548953Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 548953
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH:9]([NH2:12])([CH3:11])[CH3:10].C(N(CC)CC)C>C(#N)C>[Cl:1][C:2]1[N:7]=[C:6]([NH:12][CH:9]([CH3:11])[CH3:10])[CH:5]=[CH:4][N:3]=1

Komponenten

5

Edukt 3

HCID 6363IsopropylamineHCID 8471TriethylamineHCID 775312,4-Dichloropyrimidine

Produkt 1

HCID 202849702-Chloro-N-isopropyl-4-pyrimidinamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

In analogy to compound 1.1, a solution of 0.347 g (2.33 mmol) of 2,4-dichloro-pyrimidine in 15 ml of acetonitrile is reacted with 0.22 ml (2.52 mmol) of isopropylamine in the presence of 0.39 ml (2.83 mmol) of triethylamine. Purification by chromatography (silica gel, ethyl acetate/hexane with ethyl acetate 0-100%) results in 0.26 g (65% of theory) of the product.

Aufarbeitung

  1. customPurification by chromatography (silica gel, ethyl acetate/hexane with ethyl acetate 0-100%)
  2. customresults in 0.26 g (65% of theory) of the product

Quellen und Nachweise

ORD-Eintrag
ord-195e515122f344739517d1768bca294f
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07943629B2

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