Tetrahydrofuran → 5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone

HRID 5512

Reaktionsgleichung

Reaktionsgleichung von HRID 5512
Cl[CH2:2][C:3]1[CH2:8][C:7](=[O:9])[C:6]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:5][N:4]=1.O1CCCC1.Cl.[CH3:24][NH:25][CH3:26].[OH-].[Na+]>O>[CH2:11]([O:10][C:6]1[C:7](=[O:9])[CH2:8][C:3]([CH2:2][N:25]([CH3:26])[CH3:24])=[N:4][CH:5]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Komponenten

6

Edukt 4

HCID 8028TetrahydrofuranHCID 10473Dimethylamine, hydrochlorideHCID 14798Sodium HydroxideHCID 677480612-Chloromethyl-5-benzyloxy-4-pyridone

Produkt 1

HCID 677480495-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridoneAusbeute 96,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a mixture of 2-chloromethyl-5-benzyloxy-4-pyridone (1.0 g), tetrahydrofuran (10 ml) and water (10 ml) were added dimethylamine hydrochloride (1.31 g) and sodium hydroxide (0.64 g). After being stirred for 1.5 hours, the mixture was concentrated under reduced pressure to dryness. The residue was dissolved in methanol and the insoluble material was filtered off. The filtrate was evaporated in vacuo to give 5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone (1.0 g) as a powder.

Aufarbeitung

  1. concentrationthe mixture was concentrated under reduced pressure to dryness
  2. dissolutionThe residue was dissolved in methanol
  3. filtrationthe insoluble material was filtered off
  4. customThe filtrate was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5543a960e72d4b11830530e7308453a5
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05244890

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