Water → HCID 20115238, Verbindung

HRID 558127Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 558127
[BH4-].[Na+].[Br:3][C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[C:11]1[CH2:12][CH2:13][CH2:14][N:15]=1.O.[OH-].[Na+]>CO.C(O)(=O)C>[Br:3][C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[CH:11]1[CH2:12][CH2:13][CH2:14][NH:15]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 574450765-(2-bromo-4-fluorophenyl)-3,4-dihydro-2H-pyrrole

Produkt 1

HCID 20115238HCID 20115238, VerbindungAusbeute 71 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 10129899Acetic acid methanolLösungsmittel

Versuchsvorschrift

Add sodium tetrahydroborate (146 mg, 3.7 mmol) to a solution of 5-(2-bromo-4-fluorophenyl)-3,4-dihydro-2H-pyrrole (420 mg, 1.73 mmol) in methanol-acetic acid (saturated; 10 mL) mixture at −40° C. After warming up to RT, add water (10 mL) and make the solution basic with a NaOH solution (2 N). Extract the solution with DCM, wash the organic solution with aqueous saturated sodium chloride, dry over potassium carbonate, and remove the organic solvent to give the title compound (300 mg, 71%). MS (ES) m/z 236 [M+1]+.

Aufarbeitung

  1. extractionExtract the solution with DCM
  2. washwash the organic solution with aqueous saturated sodium chloride
  3. dry with materialdry over potassium carbonate
  4. customremove the organic solvent

Quellen und Nachweise

ORD-Eintrag
ord-8c8e5aeb3e304a5ebdf2f07233827352
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063035B2

Notizen zur Reaktion

Wird geladen…