1,3-Dimethyl-5-nitroisoquinoline → 1,3-Dimethylisoquinolin-5-amine

HRID 559476

Reaktionsgleichung

Reaktionsgleichung von HRID 559476
[CH3:1][C:2]1[C:11]2[C:6](=[C:7]([N+:12]([O-])=O)[CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([CH3:15])[N:3]=1>[Pd].CO>[NH2:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[CH:5]=[C:4]([CH3:15])[N:3]=[C:2]2[CH3:1]

Komponenten

4

Edukt 1

HCID 574567801,3-Dimethyl-5-nitroisoquinoline

Produkt 1

HCID 223376241,3-Dimethylisoquinolin-5-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of D3 (2.01 g, 9.94 mM) and 10% palladium on charcoal (1 g) in methanol was hydrogenated at atmospheric pressure for 1 h. The catalyst was filtered off and the filtrate concentrated under reduced pressure to afford the title compound as an off white solid.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8b298f91f862430fb1b4d0d9f7fe359c
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063078B2

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