2-Furanpropionic acid → 3-(Oxolan-2-yl)propanoic acid

HRID 56215

Reaktionsgleichung

Reaktionsgleichung von HRID 56215
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([OH:10])=[O:9]>CO.[Pd]>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][CH2:7][C:8]([OH:10])=[O:9]

Komponenten

4

Edukt 1

HCID 702862-Furanpropionic acid

Produkt 1

HCID 2631613-(Oxolan-2-yl)propanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 3-(furan-2-yl)propanoic acid (11.0 g, 80.0 mmol) and Pd/C (1.1 g, 10%) in MeOH (110 mL) was stirred at 60° C. under 30 bar of H2 overnight. The mixture was then filtered and the filtrate was concentrated in vacuo to give the title compound, which was used for next step without further purification.

Aufarbeitung

  1. filtrationThe mixture was then filtered
  2. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9f3c11f0258740c08bd5d0b5b6d2e178
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434695B2

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