5-Bromo-2-fluorobenzaldehyde → (5-Bromo-2-fluorophenyl)methanol
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH:9]=1)[CH:7]=[O:8].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH2:7][OH:8])[CH:9]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 5-bromo-2-fluorobenzaldehyde (1.3 g, 6.4 mmol) in MeOH (10 mL) was added sodium borohydride (0.29 g, 7.7 mmol), and the reaction was stirred at room temperature for 5 minutes. After aqueous work-up, the residue was purified by silica gel chromatography to give the title compound.
Aufarbeitung
- customAfter aqueous work-up, the residue was purified by silica gel chromatography
Quellen und Nachweise
- ORD-Eintrag
- ord-e013470df19541eaa101c5ba8cb8d399
- Quelldatensatz
- uspto-grants-2011_11
- Patentnummer
- US08067445B2
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