Potassium Hydroxide → 4-(m-Toluidino)-1-benzylpiperidine-4-carboxylic acid

HRID 565603Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 565603
[CH2:1]([N:8]1[CH2:16][CH2:15][C:11]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=2)([C:12](N)=[O:13])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:25].[K+]>C(O)CO.O.C(O)(=O)C>[CH2:1]([N:8]1[CH2:16][CH2:15][C:11]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=2)([C:12]([OH:25])=[O:13])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

6

Edukt 2

HCID 14797Potassium HydroxideHCID 211931981-Benzyl-4-(3-methylphenylamino)isonipecotamide

Produkt 1

HCID 211934454-(m-Toluidino)-1-benzylpiperidine-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 174Ethylene GlycolLösungsmittelHCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 1-benzyl-4-(3-methylphenylamino)isonipecotamide (4.5 g, 13.9 mmol), as described above in Example 2, Step B, and potassium hydroxide (3.g, 53.5 mmol) in ethylene glycol (35 mL) was heated under reflux. The resulting mixture was diluted with water and neutralized with acetic acid. The white solid precipitated was filtered, washed with chloroform to provide 1-benzyl-4-(3-methylphenylamino)piperidine-4-carboxylic acid.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux
  3. customThe white solid precipitated
  4. filtrationwas filtered
  5. washwashed with chloroform

Quellen und Nachweise

ORD-Eintrag
ord-f737e724aa864c3fbe88e766adc1a39b
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06172076B2

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