Tetrahydrofuran → N-(4-aminobenzyl)-N-(2-pyridinyl)amine

To a solution of nickel bromide (44 mg) in methanol (4 ml)/THF (4 ml) was added sodium boro hydride (40 mg), and the mixture was stirred. To the mixture was added 2-[(4-nitrophenyl)methylamino]pyridine (0.92 g) and then sodium boro hydride (414 mg), and the mixture was stirred at room temperature for 1 hour. To the mixture was added nickel bromide (44 mg)and sodium boro hydride (454 mg), and the mixture was stirred at room temperature for 2 hours. Insoluble materials were filtered off with sellaite, and to the filtrate was added sodium bicarbonate solution. The mixture was extracted with ethyl acetate and washed with brine. The extract was dried (anhydrous magnesium sulfate) and concentrated, and the residue was purified twice with silica gel column chromatography (ethyl acetate/hexane=1/1) to give 2-[(4-aminophenyl)methylamino]pyridine (369 mg) as pale red solid.

1. stirringthe mixture was stirred at room temperature for 2 hours
2. filtrationInsoluble materials were filtered off with sellaite
3. additionto the filtrate was added sodium bicarbonate solution
4. extractionThe mixture was extracted with ethyl acetate
5. washwashed with brine
6. dry with materialThe extract was dried (anhydrous magnesium sulfate)
7. concentrationconcentrated
8. customthe residue was purified twice with silica gel column chromatography (ethyl acetate/hexane=1/1)

ORD-Eintrag

ord-2599ca3dabad412daf53f723b3dd665d

Quelldatensatz

uspto-grants-2001_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06172061B2