Water → HCID 21265864, Verbindung

HRID 566255Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 566255
[CH:1]1[N:2]=[C:3]([CH2:10][C:11](OC)=[O:12])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.[BH4-].[Na+].O>CO>[CH:1]1[N:2]=[C:3]([CH2:10][CH2:11][OH:12])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

Komponenten

5

Edukt 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 21265856HCID 21265856, Verbindung

Produkt 1

HCID 21265864HCID 21265864, VerbindungAusbeute 88,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

Methyl 2-(imidazo[1,5-a]pyridin-3-yl)acetate (1.85 g) was dissolved in methanol (30 ml). To the solution was added sodium borohydride (3.68 g), and the mixture was stirred for one hour at 60° C. To the reaction mixture was added water (20 ml), which was concentrated under reduced pressure. The concentrate was subjected to extraction twice with ethyl acetate (40 ml). The organic layers were combined and dried over anhydrous magnesium sulfate, followed by concentration to afford the title compound (1.39 g).

Aufarbeitung

  1. concentrationwas concentrated under reduced pressure
  2. extractionThe concentrate was subjected to extraction twice with ethyl acetate (40 ml)
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationfollowed by concentration

Quellen und Nachweise

ORD-Eintrag
ord-8bb3c0dc0e4743dfb19d1f1c560f125f
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06174877B1

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