2-Bromopropionic acid → Hydrochloric Acid

HRID 56698

Reaktionsgleichung

Reaktionsgleichung von HRID 56698
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]2[C:15]([Cl:16])=[CH:14][NH:13][C:12](=[O:17])[CH:11]=2)[CH:3]=1.Br[CH:19]([CH3:23])[C:20]([OH:22])=[O:21]>>[Cl:16][C:15]1[C:10]([C:4]2[CH:3]=[C:2]([Cl:1])[CH:9]=[CH:8][C:5]=2[C:6]#[N:7])=[CH:11][C:12](=[O:17])[N:13]([CH:19]([CH3:23])[C:20]([OH:22])=[O:21])[CH:14]=1.[ClH:1]

Komponenten

4

Edukt 2

HCID 117292-Bromopropionic acidHCID 1176052214-Chloro-2-(5-chloro-2-oxo-1,2-dihydropyridin-4-yl)benzonitrile

Produkt 2

HCID 313Hydrochloric AcidHCID 1176225492-[5-Chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid

Versuchsvorschrift

910 mg (purity 57%, 1.96 mmol) of 4-chloro-2-(5-chloro-2-oxo-1,2-dihydropyridin-4-yl)benzonitrile and 1.5 eq. of 2-bromopropanoic acid (racemate) were reacted according to General Method 4A, initially at RT for 2.5 h and then at 45° C. overnight. The desired product was obtained by precipitation with hydrochloric acid. Yield: 1.06 g (purity 78%, quant.)

Aufarbeitung

  1. customat 45° C.
  2. customovernight

Quellen und Nachweise

ORD-Eintrag
ord-3bf6cf3c49e5403095b732419e13cb77
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434690B2

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