2-(2,6-Difluoro-phenyl)-7-nitro-benzo[d][1,3]oxazin-4-one → 7-Amino-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one

HRID 567684Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 567684
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[C:12](=[O:13])[O:11][C:10]([C:14]3[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=3[F:21])=[N:9][C:8]=2[CH:22]=1)([O-])=O>C(O)(=O)C.O=[Pt]=O>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[C:12](=[O:13])[O:11][C:10]([C:14]3[C:15]([F:21])=[CH:16][CH:17]=[CH:18][C:19]=3[F:20])=[N:9][C:8]=2[CH:22]=1

Komponenten

4

Edukt 1

HCID 104477332-(2,6-Difluoro-phenyl)-7-nitro-benzo[d][1,3]oxazin-4-one

Produkt 1

HCID 98819927-Amino-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

7-Nitro-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one (0.10 g) was dissolved in acetic acid (10 mL) under N2, PtO2 (5 mg) was added and the mixture was hydrogenated with H2 gas. Reaction time 1 day. The reaction mixture was filtered through Hyflo®, which was rinsed afterwards with ethyl acetate. The combined organic phases were evaporated to dryness and subsequently treated three times with toluene followed by evaporation.

Aufarbeitung

  1. customReaction time 1 day
  2. filtrationThe reaction mixture was filtered through Hyflo®, which
  3. washwas rinsed afterwards with ethyl acetate
  4. customThe combined organic phases were evaporated to dryness
  5. additionsubsequently treated three times with toluene
  6. customfollowed by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-1d1d3e34ba904e49bc320da92f48fc2d
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06180625B2

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