Pyridinium chloride → 3-(2-Fluorophenyl)-6-hydroxy-7-methyl-1,2-benzisoxazole

HRID 568655Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 568655
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]2[CH:13]=[CH:14][C:15]([O:18]C)=[C:16]([CH3:17])[C:11]=2[O:10][N:9]=1.Cl.N1C=CC=CC=1>O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]2[CH:13]=[CH:14][C:15]([OH:18])=[C:16]([CH3:17])[C:11]=2[O:10][N:9]=1

Komponenten

4

Edukt 2

HCID 10176127Pyridinium chlorideHCID 130157283-(2-Fluorophenyl)-6-methoxy-7-methyl-1,2-benzisoxazole

Produkt 1

HCID 1355896433-(2-Fluorophenyl)-6-hydroxy-7-methyl-1,2-benzisoxazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

3-(2-fluorophenyl)-6-methoxy-7-methyl-1,2-benzisoxazole (16.1 g) is heated at 200° C. for two hours with 64 g of pyridine hydrochloride. The melt is poured into H2O and extracted with ethyl acetate. After washing with 5% HCl the ethyl acetate is dried and evaporated to give 3-(2-fluorophenyl)-6-hydroxy-7-methyl-1,2-benzisoxazole, mp 216°-219° C.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washAfter washing with 5% HCl the ethyl acetate
  3. customis dried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-1d1ab942513043c497b432d2e93cd102
Quelldatensatz
uspto-grants-1988_03
Patentnummer
US04728662

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