Water → 4-(2-Iodoethyl)-1,2-dimethoxybenzene

HRID 568782Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 568782
CS(O[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH3:17])[CH:9]=1)(=O)=O.[I-:18].[Na+].O>CC(C)=O>[CH3:17][O:16][C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][C:11]=1[O:14][CH3:15])[CH2:7][CH2:6][I:18]

Komponenten

5

Edukt 3

HCID 962WaterHCID 5238Sodium IodideHCID 112076823,4-Dimethoxyphenethyl methanesulfonate

Produkt 1

HCID 5970224-(2-Iodoethyl)-1,2-dimethoxybenzeneAusbeute 92,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a flask was added 21.2 g (0.078 mole) of 2-(3,4-dimethoxyphenyl)ethyl methanesulfonate and 44.65 g (0.3 mole) of sodium iodide in 420 ml of acetone. The solution was refluxed for 2 hr, poured into water, washed with brine, dried over MgSO4, and evaporated to give 21.1 g of a yellow oil. The oil was recrystallized in MeOH to give 17.1 g of product, mp 43°-46° C.

Aufarbeitung

  1. temperatureThe solution was refluxed for 2 hr
  2. washwashed with brine
  3. dry with materialdried over MgSO4
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-57623c082a6a4f979b0f7fd2560088e7
Quelldatensatz
uspto-grants-1988_03
Patentnummer
US04729994

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