2-Methoxyacetohydrazide → HCID 178494722, Verbindung

HRID 570338

Reaktionsgleichung

[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([C:12]([O:14]CC)=[O:13])=[CH:10][N:11]=2)[CH:8]=1)#[N:2].[CH3:17][O:18][CH2:19][C:20]([NH:22][NH2:23])=O.C[O-].[Na+]>C(OCCO)C>[CH3:17][O:18][CH2:19][C:20]1[N:2]=[C:1]([C:3]2[CH:4]=[CH:5][C:6]3[N:7]([C:9]([C:12]([OH:14])=[O:13])=[CH:10][N:11]=3)[CH:8]=2)[NH:23][N:22]=1

Komponenten

Reaktionsbedingungen

Temperatur: 110 °C

Versuchsvorschrift

To a solution of ethyl 6-cyanoimidazo[1,2-a]pyridine-3-carboxylate (24q) (265 mg, 1.23 mmol) and 2-methoxyacetohydrazide (193 mg, 1.85 mmol) in 2-ethoxyethanol (5 mL) was added NaOMe (0.5 M in MeOH, 3.7 mL). The mixture was heated at 110° C. in a sealed vial overnight. The reaction mixture was purified by HPLC to give 6-(3-(methoxymethyl)-1H-1,2,4-triazol-5-yl)imidazo[1,2-a]pyridine-3-carboxylic acid (99). MS m/z 274.1 (M+1)+.

Aufarbeitung

customThe reaction mixture was purified by HPLC

Quellen und Nachweise

ORD-Eintrag: ord-f65e2950893e4c878f6533523c7a9f18
Quelldatensatz: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09023839B2

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