Hydrochloric Acid → 3'-Methoxypropiophenone

To a stirred solution of 3-(methyloxy)benzaldehyde (0.895 mL, 7.34 mmol) in diethyl ether (10 mL) cooled in an ice bath was added ethylmagnesium bromide (1.0M solution in THF) (11.02 mL, 11.02 mmol), the solution was stirred for 3 h in an ice bath, after which aqueous HCl (0.6M) (20 mL) was added. The aqueous layer was then extracted with DCM (4×30 mL), the combined organic extracts were dried over a phase separating column and concentrated. The residue was used in the next step without any further purification. To a solution of oxalyl chloride (0.964 mL, 11.02 mmol) in DCM (4 mL) cooled to −78° C. was added DMSO (1.042 mL, 14.69 mmol) dropwise, followed by a solution of the material isolated in the first step in DCM (6 mL). The resulting mixture was stirred for 1 h at −78° C. before the addition of triethylamine (5.12 mL, 36.7 mmol), after which the reaction mixture was stirred at −78° C. for 1 h. The reaction was quenched at −78° C. by water (20 mL). The aqueous layer was then extracted with DCM (3×50 mL), the combined organic extracts were dried over a phase separating column and concentrated. Purification by chromatography on silica gel, eluting with a gradient of 0-25% ethyl acetate in cyclohexane, afforded the title compound (1.126 g). LCMS (A) m/z: 165 [M+1]+, Rt 1.32 min (basic).

1. extractionThe aqueous layer was then extracted with DCM (4×30 mL)
2. customthe combined organic extracts were dried over a phase
3. customseparating column
4. concentrationconcentrated
5. customThe residue was used in the next step without any further purification
6. stirringafter which the reaction mixture was stirred at −78° C. for 1 h
7. customThe reaction was quenched at −78° C. by water (20 mL)
8. extractionThe aqueous layer was then extracted with DCM (3×50 mL)
9. customthe combined organic extracts were dried over a phase
10. customseparating column
11. concentrationconcentrated
12. customPurification by chromatography on silica gel
13. washeluting with a gradient of 0-25% ethyl acetate in cyclohexane

ORD-Eintrag

ord-63c96ede63a541c3994b46505fd7ea3b

Quelldatensatz

uspto-grants-2015_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09029545B2