Sodium Acetate → HCID 58442356, Verbindung

HRID 574238Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 574238
[CH2:1]([O:3][C:4](=[O:10])[CH:5]([NH2:9])[C:6](=[NH:8])[NH2:7])[CH3:2].[CH:11]([C:13]([C:15]([F:18])([F:17])[F:16])=O)=O.C([O-])(=O)C.[Na+]>O>[CH2:1]([O:3][C:4]([C:5]1[C:6]([NH2:7])=[N:8][C:13]([C:15]([F:18])([F:17])[F:16])=[CH:11][N:9]=1)=[O:10])[CH3:2]

Komponenten

5

Edukt 3

HCID 517045Sodium AcetateHCID 27790243,3,3-Trifluoro-2-oxopropanalHCID 12439913HCID 12439913, Verbindung

Produkt 1

HCID 58442356HCID 58442356, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a mixture of amino-carbamimidoyl-acetic acid ethyl ester (2 g, 9.22 mmol) and water (50 ml), a 20% aqueous solution of trifluoropyruvic aldehyde (2.32 g, 18.43 mmol) was added. To this mixture, sodium acetate (5.29 g, 64.52 mmol) was added (pH of the reaction mixture was pH5). The reaction mixture was left to stir at RT overnight. The resultant precipitate was filtered under vacuum purification by chromatography on silica eluting with iso-hexane:EtOAc (gradient of 0 to 10% EtOAc) afforded the title compound

Aufarbeitung

  1. waitThe reaction mixture was left
  2. filtrationThe resultant precipitate was filtered under vacuum purification by chromatography on silica eluting with iso-hexane

Quellen und Nachweise

ORD-Eintrag
ord-6306c237045a4a93aa9ab2ddd5803deb
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09034879B2

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