Hydrochloric Acid → 3-Amino-5,6-bis(trifluoromethyl)pyrazine-2-carbohydrazide

HRID 574241Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 574241
[NH2:1][C:2]1[C:3]([C:16](OCC)=[O:17])=[N:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1.O.[NH2:22][NH2:23].Cl>CO.O>[NH2:1][C:2]1[C:3]([C:16]([NH:22][NH2:23])=[O:17])=[N:4][C:5]([C:12]([F:14])([F:15])[F:13])=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 24654Hydrazine hydrate (1:1)HCID 86657667Ethyl 3-amino-5,6-bis(trifluoromethyl)pyrazine-2-carboxylate

Produkt 1

HCID 867296083-Amino-5,6-bis(trifluoromethyl)pyrazine-2-carbohydrazide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A suspension of ethyl 3-amino-5,6-bis(trifluoromethyl)pyrazine-2-carboxylate (Int. G1)(455 mg, 1.501 mmol) in MeOH (10 ml) was treated with hydrazine monohydrate (0.147 ml, 3.00 mmol) and stirred at RT overnight. The reaction mixture was diluted with water (50 ml) and the pH was adjusted to pH4-5 using 1M HCl. A yellow precipitate formed which was filtered under vacuum, washed with water and air dried to afford the title compound which was used without further purification;

Aufarbeitung

  1. customA yellow precipitate formed which
  2. filtrationwas filtered under vacuum
  3. washwashed with water and air
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-4b9721b5aba7433ebc7a754459f50caa
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09034879B2

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