Methylphenidate Hydrochloride → Methylphenidate

HRID 574653

Reaktionsgleichung

Reaktionsgleichung von HRID 574653
[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:4].Cl>O>[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4]

Komponenten

3

Edukt 1

HCID 9280Methylphenidate Hydrochloride

Produkt 1

HCID 4158Methylphenidate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

In a preferred manufacturing process, methylphenidate HCl and microcrystalline cellulose (Avicel PH-101) are blended in a Hobart Mixer. Purified water is added to the dry mixture and the wet granulation is extruded (MG-55 Multi granulator). The extrudate is then spheronized into pellets (Caleva Model# SPH250). The wet pellets are dried (Fluid Air Model#0050) and sieved (30 mesh<Acceptable<20 mesh).

Aufarbeitung

  1. customThe wet pellets are dried (Fluid Air Model#0050)
  2. filtrationsieved (30 mesh<Acceptable<20 mesh)

Quellen und Nachweise

ORD-Eintrag
ord-12517afc368e49b784f3677fab99936b
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09034902B2

Verknüpfte Notizen

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