N-methyl-5-nitro-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine → N2-methyl-N2-(tetrahydro-2H-pyran-4-yl)-2,5-Pyridinediamine

HRID 57550

Reaktionsgleichung

Reaktionsgleichung von HRID 57550
[CH3:1][N:2]([CH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)[C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][N:4]=1>CO.[Pd]>[CH3:1][N:2]([CH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][N:4]=1

Komponenten

4

Edukt 1

HCID 71113503N-methyl-5-nitro-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine

Produkt 1

HCID 43610738N2-methyl-N2-(tetrahydro-2H-pyran-4-yl)-2,5-Pyridinediamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

To a solution of N-methyl-5-nitro-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine (217 mg, 0.92 mmol) in MeOH (30 mL) was added Pd/C (0.5 g). The mixture was stirred for 3 hours at 20° C. under 1 atm. H2. The reaction was filtered and concentrated to give dark red oil. MS (m/z): 208 (M+H)+

Aufarbeitung

  1. filtrationThe reaction was filtered
  2. concentrationconcentrated
  3. customto give dark red oil

Quellen und Nachweise

ORD-Eintrag
ord-3bdf9a7e1e4441f8bbbb21f22db9e522
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434726B2

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