Sodium Hydroxide → 2-Chloro-6-iodo-4-(trifluoromethyl)aniline

HRID 576039

Reaktionsgleichung

Reaktionsgleichung von HRID 576039
[I:1]Cl.[Cl:3][C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH2:14].[OH-].[Na+]>Cl.O>[Cl:3][C:4]1[CH:9]=[C:8]([C:10]([F:12])([F:13])[F:11])[CH:7]=[C:6]([I:1])[C:5]=1[NH2:14]

Komponenten

6

Edukt 3

HCID 14798Sodium HydroxideHCID 24640Iodine chlorideHCID 1620012-Chloro-4-trifluoromethylaniline

Produkt 1

HCID 565876962-Chloro-6-iodo-4-(trifluoromethyl)anilineAusbeute 97,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittel2×HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

Iodine monochloride (17.2 g, 108 mmol) in hydrochloric acid (36%, 21.4 g) and water (35 mL) was added dropwise to 2-chloro-4-(trifluoromethyl)benzenamine (20.0 g, 102 mmol) in hydrochloric acid (36%, 20.7 g) and water (140 mL). The mixture was warmed to 50° C. for a total of 8 h. Sodium hydroxide (50%, 33.5 g, 419 mmol) was added to the mixture at room temperature. The mixture was extracted with dichloromethane (2×250 mL), and the extracts were dried and evaporated to give the product as an oil (31.83 g, 97% yield).

Aufarbeitung

  1. extractionThe mixture was extracted with dichloromethane (2×250 mL)
  2. customthe extracts were dried
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-9db113ea38b14b2ea96e8bc669de7892
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09035101B2

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