Hydrochloric Acid → HCID 66644546, Verbindung

To a solution of (S)-benzyl 3-(4-(benzyloxy)phenyl)-2-(2-(3-(3-benzylureido)propanoyl)-1-methylhydrazinyl)propanoate (Compound XVII-1) 149 mg (0.25 mmol) in tetrahydrofuran:methanol=1:1.5 1.5 ml, a solution of lithium hydroxide monohydrate 16 mg in water 0.3 ml was added and the mixture was stirred at room temperature for 1.5 hr. The reaction mixture was cooled to 0° C. and 1N HCl aq. 10 ml was added and the mixture was extracted with ethyl acetate 20 ml. The organic phase was washed with water 20 ml and brine 20 ml and dried over magnesium sulfate and filtered. The mother solution was concentrated in vacuo to obtain the title compound. The residue was used without further purification.

1. temperatureThe reaction mixture was cooled to 0° C.
2. extractionthe mixture was extracted with ethyl acetate 20 ml
3. washThe organic phase was washed with water 20 ml and brine 20 ml
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. concentrationThe mother solution was concentrated in vacuo

ORD-Eintrag

ord-76ef4c7783254959b6bdbc58b026f2bf

Quelldatensatz

uspto-grants-2015_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09040531B2