Olprinone → 5-(3-Bromoimidazo[1,2-a]pyridin-6-yl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile hydrobromide

HRID 579960Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 579960
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([C:10]3[CH:11]=[C:12]([C:18]#[N:19])[C:13](=[O:17])[NH:14][C:15]=3[CH3:16])[CH:7]=[CH:6][C:5]=12.[Br:20]Br>C(O)(=O)C>[BrH:20].[Br:20][C:3]1[N:4]2[CH:9]=[C:8]([C:10]3[CH:11]=[C:12]([C:18]#[N:19])[C:13](=[O:17])[NH:14][C:15]=3[CH3:16])[CH:7]=[CH:6][C:5]2=[N:1][CH:2]=1

Komponenten

4

Edukt 2

HCID 4593OlprinoneHCID 24408Bromine

Produkt 1

HCID 212764285-(3-Bromoimidazo[1,2-a]pyridin-6-yl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile hydrobromideAusbeute 155,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
30 °C

Versuchsvorschrift

In 10 ml of acetic acid was dissolved 0.3 g of 1,2-dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile. To the solution 0.2 g of bromine was added and the mixture was warmed to 30° C. After cooling, precipitated white crystals were taken by filtration. After washing with ether, the crystals were recrystallized from methanol to obtain 0.4 g of 5-(3-bromoimidazo[1,2-a]pyridin-6-yl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile hydrobromide.

Aufarbeitung

  1. temperatureAfter cooling
  2. customprecipitated white crystals
  3. filtrationwere taken by filtration
  4. washAfter washing with ether
  5. customthe crystals were recrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-ad65462674d54322ac78df64391b3adf
Quelldatensatz
uspto-grants-1988_06
Patentnummer
US04751227

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