Diethyl Ether → 2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione

HRID 580118Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 580118
O1CCOCC1.[NH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][N:9]=1.[C:17]1(=O)[O:22][C:20](=[O:21])[C:19]2=[CH:23][CH:24]=[CH:25][CH:26]=[C:18]12.C(OCC)C>O>[C:17]1(=[O:22])[N:7]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][N:9]=2)[C:20](=[O:21])[C:19]2=[CH:23][CH:24]=[CH:25][CH:26]=[C:18]12

Komponenten

6

Edukt 4

HCID 3283Diethyl EtherHCID 6811Phthalic AnhydrideHCID 133991H-indazol-3-amineHCID 312751,4-Dioxane

Produkt 1

HCID 27558572-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dioneAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To 50 ml of dioxane were added 5.0 g of 3-aminoindazole thus obtained and 6.68 g of phthalic anhydride, and the mixture was stirred for 5 hours at 120° C. After the mixture was condensed under reduced pressure, the condensed residue was added with 30 ml of diethyl ether and stirred under cooling with ice and water for 30 minutes to separate crystals. Then the crystals were obtained by filtration and dried under reduced pressure to give 8.6 g of 3-phthalimidoindazole having the following analytical values in a yield of 87%.

Aufarbeitung

  1. customthus obtained
  2. customcondensed under reduced pressure
  3. customto separate crystals
  4. customThen the crystals were obtained by filtration
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-329e63e25bce4dd8a5bb5671c824753d
Quelldatensatz
uspto-grants-1988_06
Patentnummer
US04751302

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