Methanesulfonyl chloride → N-(5-Bromo-6-methyl-2-pyridinyl)methanesulfonamide

HRID 58038

Reaktionsgleichung

Reaktionsgleichung von HRID 58038
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:9])=[N:6][C:7]=1[CH3:8].C(N(C(C)C)C(C)C)C.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:9][S:20]([CH3:19])(=[O:22])=[O:21])=[N:6][C:7]=1[CH3:8]

Komponenten

5

Edukt 3

HCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 1706782-Pyridinamine, 5-bromo-6-methyl-

Produkt 1

HCID 79049128N-(5-Bromo-6-methyl-2-pyridinyl)methanesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a mixture of 5-bromo-6-methylpyridin-2-amine (0.3 g, 1.604 mmol) and N-ethyl-N-isopropylpropan-2-amine (0.559 mL, 3.21 mmol) in DCM (10 mL) was added methanesulfonyl chloride (0.137 mL, 1.764 mmol) at 0° C. The reaction mixture was stirred at room temperature for 48 hours and was subsequently concentrated in vacuo to give the title compound.

Aufarbeitung

  1. concentrationwas subsequently concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-eff90a1b5e1d49ba85eea4a95d9dbafd
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434743B2

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