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Ammonia → 5,6,7,8-Tetrahydro-2-phenyl-3-(benzoylaminoiminomethyl)imidazo[2,1-b]benzothiazole

HRID 580926
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 580926
[C:1]1([C:7]2[N:8]=[C:9]3[N:13]([C:14]=2[CH:15]=O)[C:12]2[CH2:17][CH2:18][CH2:19][CH2:20][C:11]=2[S:10]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:21]([NH:29][NH2:30])(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.Cl.C(O)C.N>O>[C:1]1([C:7]2[N:8]=[C:9]3[N:13]([C:14]=2[CH:15]=[N:30][NH:29][C:21](=[O:28])[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:12]2[CH2:17][CH2:18][CH2:19][CH2:20][C:11]=2[S:10]3)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1
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Komponenten

6

Edukt 4

HCID 222AmmoniaHCID 11955BenzoylhydrazineHCID 107316142-Phenyl-4,5,6,7,8-pentahydroimidazo[2,1-b]benzothiazole-3-carbaldehydeHCID 21887872Ethanol hydrochloride

Produkt 1

HCID 23145105,6,7,8-Tetrahydro-2-phenyl-3-(benzoylaminoiminomethyl)imidazo[2,1-b]benzothiazoleAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

0.28 g of 5,6,7,8-tetrahydro-2-phenyl-3-formylimidazo[2,1-b]benzothiazole and 0.15 g of benzohydrazide were stirred over night in 20 ml of a 0.1N hydrochloric acid-ethanol solution at room temperature and the precipitated crystal obtained by filtration. The crystals were dissolved in water and the solution was made alkaline by ammonia solution, then extracted by chloroform. The extract was washed with water and dried, then the solvent was distilled off and the residue was crystallized from ethyl acetate to obtain the desired substance in an amount of 0.35 g (yield of 84.0%).

Aufarbeitung

  1. customthe precipitated crystal obtained by filtration
  2. extractionextracted by chloroform
  3. washThe extract was washed with water
  4. customdried
  5. distillationthe solvent was distilled off
  6. customthe residue was crystallized from ethyl acetate
  7. customto obtain the desired substance in an amount of 0.35 g (yield of 84.0%)

Quellen und Nachweise

ORD-Eintrag
ord-6b09b8036967419295bf960b4f73ea62
Quelldatensatz
uspto-grants-1999_07
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05919799

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