Hydrochloric Acid → Methyl 4-[2-(imidazol-2-yl)ethyl]benzoate hydrochloride

HRID 583686Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 583686
[C:1]([CH2:3][CH2:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)#[N:2].CO.[ClH:17].CO[CH:20](OC)[CH2:21][NH2:22]>CCOCC>[ClH:17].[NH:2]1[CH:20]=[CH:21][N:22]=[C:1]1[CH2:3][CH2:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 89728Aminoacetaldehyde dimethyl acetalHCID 13308299Methyl 4-(2-cyanoethyl)benzoate

Produkt 1

HCID 18928585Methyl 4-[2-(imidazol-2-yl)ethyl]benzoate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

Nitrile 23-3 (400 mg, 2.11 mmol) was dissolved in 10 mL Et2O at 0° MeOH (289 μL, 4.2 mmol) was added, the mixture was saturated with anhydrous HCl. Once the white ppt. formed, the solvent was evaporated and replaced with MeOH (5 mL), cooled to 0°, and aminoacetaldehyde dimethylacetal (250 μL, 2.3 mmol) was added. The reaction was heated to reflux for 3 days then concentrated, diluted in 10 mL 6N HCl and concentrated again providing 23-4 as a solid.

Aufarbeitung

  1. additionwas added
  2. customformed
  3. customthe solvent was evaporated
  4. temperaturecooled to 0°
  5. temperatureThe reaction was heated
  6. temperatureto reflux for 3 days
  7. concentrationthen concentrated
  8. additiondiluted in 10 mL 6N HCl
  9. concentrationconcentrated again

Quellen und Nachweise

ORD-Eintrag
ord-d853fbbf2d42476e87b82191a538b8ab
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05929120

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