Sodium Carbonate → HCID 178503197, Verbindung

HRID 584123

Reaktionsgleichung

Reaktionsgleichung von HRID 584123
Cl.[NH2:2][OH:3].C([O-])([O-])=O.[Na+].[Na+].[CH3:10][S:11][C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=1>O.CO>[OH:3][NH:2][C:16](=[NH:17])[C:15]1[CH:18]=[CH:19][C:12]([S:11][CH3:10])=[CH:13][CH:14]=1

Komponenten

6

Edukt 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 5909604-(Methylthio)benzonitrile

Produkt 1

HCID 178503197HCID 178503197, VerbindungAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

Hydroxylamine hydrochloride (104 mg, 1.5 mmol) and Na2CO3 (80 mg, 0.75 mmol) were dissolved in 0.5 mL of water. A solution of 4-methylsulfanyl-benzonitrile (223 mg, 1.5 mmol) in 4 mL of methanol was added and the combined solution was stirred at RT for about 48 h. After removal of the solvent, the precipitate was washed with water, filtered and dried to give N-hydroxy-4-methylsulfanyl-benzamidine (203 mg, 75%) which was used without further purification.

Aufarbeitung

  1. customAfter removal of the solvent
  2. washthe precipitate was washed with water
  3. filtrationfiltered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-039cdc46e35a4491b963e45525ae843a
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06924284B2

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