Benzaldehyde → 2-(Benzylamino)-2-methylpropane-1,3-diol

HRID 584227

Reaktionsgleichung

Reaktionsgleichung von HRID 584227
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:9][C:10]([CH3:15])([CH2:13][OH:14])[CH2:11][OH:12].[BH4-].[Na+].[OH-].[Na+]>CO.C(OCC)(=O)C>[CH2:1]([NH:9][C:10]([CH3:15])([CH2:13][OH:14])[CH2:11][OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

7

Edukt 4

HCID 240BenzaldehydeHCID 15312-Amino-2-methyl-1,3-propanediolHCID 14798Sodium HydroxideHCID 4311764Sodium borohydride

Produkt 1

HCID 1987392-(Benzylamino)-2-methylpropane-1,3-diol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Benzaldehyde (17.4 ml) was added dropwise to a solution of 2-amino-2-methyl-1,3-propanediol (20 g) in methanol (200 ml) at 0° C. and the whole was stirred at room temperature for 2 hours. Sodium borohydride (11.5 g) was added thereto in portions at 0° C. and the mixture was stirred for 10 minutes. 1N Sodium hydroxide solution and ethyl acetate were added and the organic layer was separated, dried over magnesium sulfate, and evaporated in vacuo to give 2-benzylamino-2-methyl-1,3-propanediol (28.54 g).

Aufarbeitung

  1. stirringin portions at 0° C. and the mixture was stirred for 10 minutes
  2. customthe organic layer was separated
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d6eaeaec6c984751a5cd14c9cb938246
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06924278B2

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