4-Bromo-1,2-dichlorobenzene → HCID 86722607, Verbindung

Temperatur

-78 °C

To a magnetically stirred solution of 4-bromo-1,2-dichlorobenzene (5.64 g, 24.98 mmol) in dry Et2O (109 mL) was added n-BuLi (10.86 mL, 24.98 mmol) via an addition funnel under a nitrogen atmosphere. The reaction mixture was stirred at −78° C. for 30 min., A solution of ethyl 2,2-difluoropropanoate (3.0 g, 21.7 mmol) in Et2O (10 mL) was added dropwise over 15 min and allowed to stir for 1 h. The reaction was then carefully quenched with 1 N HCl (4 mL) and allowed to warm to 23° C. The solution was dilute with Et2O and washed with water. The combined organic layers were dried over Na2SO4, concentrated under reduced pressure and the resulting material was purified via flash column chromatography using 100% hexanes to 5% acetone/95% hexanes as eluent. The relevant fractions were concentrated under reduced pressure to afford the title compound as a colorless oil (3.89 g, 71%): 1H NMR (400 MHz, CDCl3) δ 8.21-8.18 (m, 1H), 7.99-7.93 (m, 1H), 7.59 (dd, J=8.4, 4.2 Hz, 1H), 1.89 (t, J=19.6 Hz, 3H); 19F NMR (376 MHz, CDCl3) δ −92.08-−93.21 (m); EISMS m/z 240 ([M−H]+).

1. stirringto stir for 1 h
2. customThe reaction was then carefully quenched with 1 N HCl (4 mL)
3. temperatureto warm to 23° C
4. additionThe solution was dilute with Et2O
5. washwashed with water
6. dry with materialThe combined organic layers were dried over Na2SO4
7. concentrationconcentrated under reduced pressure
8. customthe resulting material was purified via flash column chromatography
9. concentrationThe relevant fractions were concentrated under reduced pressure

ORD-Eintrag

ord-b8abae489372478992842bf15106de19

Quelldatensatz

uspto-grants-2016_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09226501B2