Sodium Iodide → HCID 90455791, Verbindung

HRID 588910Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 588910
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]=[CH2:11].[Si]([C:16]([F:19])(F)[F:17])(C)(C)C.[Na+].[I-]>C1COCC1.CCCCCC>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]1[CH2:11][C:16]1([F:19])[F:17]

Komponenten

6

Edukt 3

HCID 5238Sodium IodideHCID 552549(Trifluoromethyl)trimethylsilaneHCID 904560122-Chloro-4-methoxy-1-vinylbenzene

Produkt 1

HCID 90455791HCID 90455791, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittelHCID 8058HexaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

The solution of 2-chloro-4-methoxy-1-vinylbenzene (290 mg, 1.72 mmol) in dry THF (4 mL) was degassed, and then TMS-CF3 and NaI were added. The mixture was stirred at 80° C. overnight. TLC (100% Hexane) showed the reaction as complete. The mixture was diluted with hexane (20 mL). The inorganic salt was removed by filtration. The filtrate was concentrate in vacuo. The residue was purified via Isolera One (Hexane=100%).

Aufarbeitung

  1. customthe reaction as complete
  2. customThe inorganic salt was removed by filtration
  3. concentrationThe filtrate was concentrate in vacuo
  4. customThe residue was purified via Isolera One (Hexane=100%)

Quellen und Nachweise

ORD-Eintrag
ord-7a05b2e6b7874c4f9c5e1c48ee4d68dc
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09227978B2

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