Acrylic Acid → HCID 178418321, Verbindung
Reaktionsgleichung
C=CC(O)=O.C(O)C(N)(CO)CO.Cl.COC(C1C=CC(O)=CC=1)=O.[CH:26]1[N:30]([CH2:31][O:32][CH:33]([CH2:36][OH:37])[CH2:34][OH:35])[C:29]2[N:38]=[C:39]([NH2:43])[N:40]=[C:41]([O-:42])[C:28]=2[N:27]=1.[Na+]>>[CH:26]1[N:30]([CH2:31][O:32][CH:33]([CH2:36][OH:37])[CH2:34][OH:35])[C:29]2[N:38]=[C:39]([NH2:43])[N:40]=[C:41]([OH:42])[C:28]=2[N:27]=1Komponenten
5
Versuchsvorschrift
The Carbopol 934P and Poloxamer 407 (BASF Corp.) are first suspended in the TRIS HCl buffer (0.1 M) and the components are mixed under agitation overnight at 4° C. to ensure complete dissolution. The methylparaben is added and further stirring allowed until complete dissolution is observed. Ganciclovir sodium is mixed in while maintaining stirring to produce a 2.0% ganciclovir mucoadhesive, thermoreversible gel formulation. The mixture is maintained below room temperature until use.