Acetic Acid → 6,7-Dihydrothieno[3,2-D]pyrimidine-2,4-diol

HRID 595058Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 595058
C(S[C:4]1[NH:5][C:6](=[O:13])[C:7]2[S:12][CH2:11][CH2:10][C:8]=2[N:9]=1)C.Cl.CC(O)=[O:17]>O>[NH:9]1[C:8]2[CH2:10][CH2:11][S:12][C:7]=2[C:6](=[O:13])[NH:5][C:4]1=[O:17]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 136096391HCID 136096391, Verbindung

Produkt 1

HCID 444731766,7-Dihydrothieno[3,2-D]pyrimidine-2,4-diolAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

To a suspension of 2-(ethylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one (2.80 g, 13.06 mmol) in water (2.0 mL) was added 2.0 mL of conc. HCl and 4.0 mL of AcOH. The mixture was heated at 110° C. overnight. The reaction was cooled and the solid that formed collected by filtration washed with water and methanol, and dried to afford a white solid, 6,7-dihydrothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, (1.80 g, 82%). Without further purification, the crude product was used directly to the next step.

Aufarbeitung

  1. temperatureThe reaction was cooled
  2. customthe solid that formed
  3. filtrationcollected by filtration
  4. washwashed with water and methanol
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-bf3dd395102f463bb6416ea3b9e6b6ff
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242993B2

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